Footage, filmed as part of a seven-month study by Humane Society International, shows the animals being seen feeding on chemicals to test drug toxicity at Inotiv Inc.’s lab in Mount Vernon. An undercover researcher worked on the facility and was commissioned to work on more than 70 toxicity studies, all of which were commissioned by more than 12 pharmaceutical companies involving more than 6,000 animals. The researcher found that greyhounds and monkeys were held by laboratory staff to forcefully drop tubes around their necks and inject medicinal chemicals into their stomachs, according to the Humane Society. Inotiv defended its investigation as “legally necessary” in the US for drug development. Scroll down for videos. Horrifying secret video shows beagle puppies whining in pain and distressed monkeys being held by the neck in an animal testing lab in Indiana The video also shows monkeys being held by the neck in holding chairs, with their arms and legs stretched and tied, while being given drugs A monkey is seen in a neck restraint system while being given medication through a tube The researcher claimed that the beagles and monkeys were restrained by staff members in the laboratory to forcefully put tubes around their necks and inject drugs with chemicals into their stomachs. The dogs were later filmed in their small cages whining and going crazy in pain. At least 80 beagle puppies have been used in toxicity tests and have been forced to swallow chemicals through a stomach tube every day for months, it is claimed. The dogs were later filmed in their small cages whining and going crazy in pain – with one of them falling to the floor – according to the charity. “The researcher saw dogs continue to take doses of substances even when they vomited, shivered and had a high fever and shortness of breath,” said the Humane Society. The video also shows monkeys being held by the neck in restraints, with their arms and legs gripped and tied while they were being given drugs, the Humane Society said. A pair of monkeys were seen hugging in the back of their cage in the video. The researcher claimed that during the research, which was conducted from August 2021 and March 2022, at least two monkeys were accidentally hung on the restraint chairs. The lab vet was also accused of failing to assess or treat seriously ill dogs and monkeys – despite crying in pain. The researcher claimed that a monkey was constantly fed chemicals despite the fact that it suffered from serious adverse effects from a drug. The vet reportedly told the technician that the monkey should be re-administered with the drug. While the technician was giving the medicine to the monkey, he said: “I’m very sorry, ma’am, maybe this is your last dose. “I hope it’s kind of because it’s torture at this point.” An undercover researcher worked on the facility and was commissioned to work on more than 70 toxicity studies, all of which were commissioned by more than 12 pharmaceutical companies involving more than 6,000 animals. In the photo: A beagle puppy in the workshop A beagle puppy was seen collapsing on the floor after receiving medication in the laboratory The video also shows monkeys being held by the neck in holding chairs, with their arms and legs stretched and tied, while being given drugs Videos and photos also show pigs with bruised skin on their backs as an obvious result of the direct application of chemicals on them, while rats – some with large growths and masses – were crammed into plastic tubes so that they could not move for procedures. At the end of the tests, the animals are killed and slaughtered to test for toxic effects on their bodies. The Humane Society urges Inotiv Inc. to release the beagles immediately and put them up for adoption – as they fear 82 will be euthanized. There is no general legal requirement for the US Food and Drug Administration to use dogs as test subjects or to kill after the test. But the Humane Society says that despite this, Inotiv “ignored their calls”, so the fate of the 82 beagles remains uncertain. “The disturbing findings in this facility can not be ignored. “We are calling for the release of beagles that we know are suffering in the laboratory today and will soon be euthanized, but that is just the beginning of our work,” said Kitty Block, CEO and President of the Humane Society of the United States. The video and photos also show pigs with bloody backs on their backs as a result of the direct application of chemicals on them A tormented monkey with a neck looks out of the railing while in the lab Scary shots show dozens of monkeys being held back while feeding on drugs A Beagle puppy climbs the wall of the cage after a drug test Block added: “We need to address the root cause of this pain. This seems to be one of the only areas in science where failure to innovate and change is accepted and, at times, encouraged. “We hope that sharing the plight of these animals will accelerate the changes made by the FDA and the pharmaceutical industry to replace obsolete animal testing with state-of-the-art technology.” Instead of using animal testing, the Humane Society points to techniques such as instrument technologies on a chip and computational modeling that can provide “more human-related results than animal testing.” Dr Lindsay Marshall, a biomedical science consultant at Humane Society International in the United Kingdom, said: “But the truth is that as long as we rely on failed animal-based testing methods, we are limiting the scope of our scientific innovation. “In drug discovery, drug safety, chemical testing, cancer research, data show that animal responses often fail to predict what will happen to humans. “Apart from inaccurate approaches, animal approaches are usually time-consuming and labor-intensive, very costly and less predictable for the human response than new, modern animal-free methodologies.” Inotiv said their research is legally required in the US to develop life-saving drugs. From historical discoveries such as the discovery of insulin through experiments in dogs to the development last year of a cure for Ebola through work on genetically modified mice and cutting-edge cancer treatments, many scientists believe that animal research is vital to medical progress. However, the tests are supposed to be carried out under strict laws and policies that specify its terms, such as cage size, room temperatures and the social needs of the animals, as well as visits to the vet and the need for hygienic surgery and postoperative care. “On April 21, 2022, the Humane Society of the United States (HSUS) published a report claiming to have placed an intruder on one of Inotiv’s research facilities in Indiana,” Inotiv told the Journal and Courier. “The leadership of Inotiv has read the HSUS press release and the corresponding report and is examining the allegations contained therein.” “Our mission at Inotiv is to help our clients become fully aware of the potential of their scientific and medical research, which ultimately contributes to a significant improvement in the lives of both humans and animals. “The research we are doing is legally required in the US to develop life-saving drugs, medical devices and biologicals.” DailyMail.com contacted Inotiv for further comments.
